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Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - Smith, Dennis A. Waterbeemd, Han van de, Walker, Don K.
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Smith, Dennis A. Waterbeemd, Han van de, Walker, Don K.:

Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - gebunden oder broschiert

2006, ISBN: 9783527313686

Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH Verlag GmbH & Co. KGaA, Gebundene Ausgabe, Auflage: 2. Auflage, 207 Seiten, Publizi… Mehr…

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Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - Smith, Dennis A. Waterbeemd, Han van de, Walker, Don K.
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Smith, Dennis A. Waterbeemd, Han van de, Walker, Don K.:

Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - gebunden oder broschiert

2006, ISBN: 9783527313686

Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH Verlag GmbH & Co. KGaA, Gebundene Ausgabe, Auflage: 2. Auflage, 207 Seiten, Publizi… Mehr…

Versandkosten:Auf Lager. Die angegebenen Versandkosten können von den tatsächlichen Kosten abweichen. (EUR 3.00) Association Terroirs Intemporels
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Dennis A. Smith, Han Waterbeemd, Don K. Walker, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor):
Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry) - gebunden oder broschiert

2006

ISBN: 9783527313686

Wiley-VCH, 2006-05-02. 2. Hardcover. Used:Good., Wiley-VCH, 2006-05-02

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Dennis A. Smith; Han van de Waterbeemd; Don K. Walker; Series Editor-Raimund Mannhold; Series Editor-Hugo Kubinyi; Series Editor-Gerd Folkers:
Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry) - gebunden oder broschiert

2006, ISBN: 9783527313686

Wiley-VCH, 2006-05-02. Hardcover. Good., Wiley-VCH, 2006-05-02

  - Versandkosten: EUR 11.45 Ergodebooks
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Smith, Dennis A.; Waterbeemd, Han; Walker, Don K.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:
Pharmacokinetics and Metabolism in Drug Design, Volume 31 - gebunden oder broschiert

2006, ISBN: 9783527313686

Wiley-VCH, 2006-05-02. Hardcover. Good., Wiley-VCH, 2006-05-02

  - Versandkosten: EUR 18.16 BooksEntirely

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Details zum Buch
Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31)

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Detailangaben zum Buch - Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31)


EAN (ISBN-13): 9783527313686
ISBN (ISBN-10): 3527313680
Gebundene Ausgabe
Erscheinungsjahr: 2006
Herausgeber: Wiley-VCH Verlag GmbH & Co. KGaA
187 Seiten
Gewicht: 0,609 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2007-05-30T15:46:56+02:00 (Zurich)
Detailseite zuletzt geändert am 2022-05-21T01:33:30+02:00 (Zurich)
ISBN/EAN: 9783527313686

ISBN - alternative Schreibweisen:
3-527-31368-0, 978-3-527-31368-6
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: gerd folkers, raimund, hugo kubinyi, dennis smith, walker, han, van waterbeemd, don smith
Titel des Buches: drug metabolism, design methods, methods and principles medicinal chemistry, metabol, meta design, pharmacokinetics drugs


Daten vom Verlag:

Autor/in: Dennis A. Smith; Han van de Waterbeemd; Don K. Walker
Titel: Methods and Principles in Medicinal Chemistry; Pharmacokinetics and Metabolism in Drug Design
Verlag: Wiley-VCH
187 Seiten
Erscheinungsjahr: 2006-02-20
Gewicht: 0,520 kg
Sprache: Englisch
125,00 € (DE)
Not available (reason unspecified)

BB; GB; Hardcover, Softcover / Chemie; Verstehen; Pharmakokinetik; Arzneimitteldesign

PHYSICOCHEMISTRY Partition and Distribution Coefficient as Measures of Lipophilicity Limitations on the Use of Octanol Further Understanding of log P Alternative Lipophilicity Scales Computational Approaches to Lipophilicity Membrane Systems to Study Drug Behaviour NEW: Dissolution and Solubility NEW: Ionisation (pKa) PHARMACOKINETICS Intravenous Administration: Volume of Distribution Intravenous Administration: Clearance Clearance and Half-Life Intravenous administration: Infusion Oral Administration Repeated Doses Development of the Unbound (Free) Drug Model Unbound Drug and Drug Action Unbound Drug Model and Barriers to Equilibrium Slow Offset Compounds Factors Governing Unbound Drug Concentration ABSORPTION The Absorption Process Dissolution Membrane Transfer Barriers to Membrane Transfer Models for Absorption Estimation Estimation of Absorption Potential Computational Approaches DISTRIBUTION Membrane Transfer Access to the Target Brain penetration Volume of Distribution and Duration Distribution and Tmax CLEARANCE The Clearance Processes Role of Transport Proteins in Drug Clearance Interplay Between Metabolic and Renal Clearance Role of Lipophilicity in Drug Clearance RENAL CLEARANCE Kidney Anatomy and Function Lipophilicity and Reabsorption by the Kidney Effect of Charge on Renal Clearance Plasma Protein Binding and Renal Clearance Balancing Renal Clearance and Absorption Renal Clearance and Drug Design METABOLIC (HEPATIC) CLEARANCE Function of Metabolism (Biotransformation) Cytochrome P450 Other oxidative processes Oxidative Metablism and Drug Design Non-Specific Esterases Prodrugs to Aid Membrane Transfer Enzymes Catalysing Drug Conjugation Stability to Conjugation Processes Pharmacodynamics and Conjugation TOXICITY Toxicity Findings Importance of dose size Toxicity of selected compound classes Stratification of Toxicity Toxicity Prediction - Computational Toxicology Toxicogenomics Enzyme Induction (CYP3A4) and Drug Design Enzyme Inhibition and Drug Design INTERSPECIES SCALING Objectives of Allometric Scaling Allometric Scaling Species Scaling: Adjusting for Maximum Life-Span Potential Species Scaling: Incorporating Differences in Metabolic Clearance Inter-Species Scaling for Clearance by Hepatic Uptake Elimination Half-Life NEW: Scaling to pharmacological effect NEW: Single animal scaling HIGH(ER) THROUGHPUT ADME STUDIES The HTS Trend Drug Metabolism and Discovery Screening Sequences Physicochemistry Absorption / Permeability Pharmacokinetics NEW: Metabolism and Inhibition NEW: The concept of ADME space Computational Approaches in PK and Metabolism Prediction Outlook

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