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ISBN: 9783527655762
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.… Mehr…
Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith:
Reactive Drug Metabolites (Mieten. Jahres-Abopreis pro Monat)ISBN: 9783527655762
Wiley-VCH Pharmacology Reactive Drug Metabolites, drug metabolites, drug metabolite toxicity, toxicophores, IADRs, catalyzing reactive metabolite formation, drug-metabolizing, new drug ca… Mehr…
Reactive Drug Metabolites als eBook Download von Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith - neues Buch
ISBN: 9783527655762
Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith e… Mehr…
2012, ISBN: 9783527655762
eBooks, eBook Download (EPUB), Auflage, [PU: Wiley-VCH], [ED: 1], Wiley-VCH, 2012
2012, ISBN: 9783527655762
[ED: 1], 1. Auflage, eBook Download (EPUB), eBooks, [PU: Wiley-VCH]
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Detailangaben zum Buch - Reactive Drug Metabolites
EAN (ISBN-13): 9783527655762
ISBN (ISBN-10): 352765576X
Erscheinungsjahr: 2012
Herausgeber: Wiley-VCH
402 Seiten
Sprache: eng/Englisch
Buch in der Datenbank seit 2012-02-08T11:30:17+01:00 (Zurich)
Detailseite zuletzt geändert am 2024-03-07T08:17:39+01:00 (Zurich)
ISBN/EAN: 9783527655762
ISBN - alternative Schreibweisen:
3-527-65576-X, 978-3-527-65576-2
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: douglas hugo, smith, kubin, kubinyi, mann, deepak, amit, raimund, doug scott, folkers, kalg
Daten vom Verlag:
Autor/in: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Titel: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Verlag: Wiley-VCH; Wiley-VCH
386 Seiten
Erscheinungsjahr: 2012-09-06
Sprache: Englisch
153,99 € (DE)
153,99 € (AT)
Available
EA; E101; E-Book; Nonbooks, PBS / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie; BB
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.Weitere, andere Bücher, die diesem Buch sehr ähnlich sein könnten:
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9783527655779 Reactive Drug Metabolites (Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith)
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