2017, ISBN: 3736996721

[EAN: 9783736996724], Neubuch, [SC: 0.0], [PU: Cuvillier Verlag Dez 2017], CHEMIE; BIOINORGANIC; CHEMISTRY; IRON-SULFUR CLUSTERS, Neuware -Iron sulfur clusters are essential cofactors inv… Mehr…

[EAN: 9783736996724], Neubuch, [SC: 0.0], [PU: Cuvillier Verlag Dez 2017], CHEMIE; BIOINORGANIC; CHEMISTRY; IRON-SULFUR CLUSTERS, Neuware -Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine thiolates, a number of clusters featuring so called alternative ligands such as histidine have been recognized in recent years. This work uses synthetic [2Fe-2S] analogues to explore the role alternative ligands play in determining the reactivity of iron sulfur clusters. Isomerization in a homoleptically coordinated cluster utilizing a mixed nitrogen- and sulfur-donating ligand is investigated as a model for ligand rearrangement processes during iron sulfur cluster biogenesis. Furthermore, a high fidelity model system for the asymmetrically ligated [2Fe-2S] cluster of mitoNEET proteins is developed and characterized in detail. This cluster and its homoleptic analogue are studied as reagents in proton coupled electron transfer processes, highlighting the role asymmetry and reorganization energy play in tuning this reactivity. The effects of the ligation pattern on entropic contributions during reduction are probed by temperature dependent electrochemical measurements. Finally, synthetic [2Fe-2S] clusters are investigated with respect to their reactivity with organic radicals, mimicking the unique reactivity of biotin synthase. 186 pp. Englisch, Books<

ISBN: 9783736996724

Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine t… Mehr…

Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine thiolates, a number of clusters featuring so called alternative ligands such as histidine have been recognized in recent years. This work uses synthetic [2Fe-2S] analogues to explore the role alternative ligands play in determining the reactivity of iron sulfur clusters. Isomerization in a homoleptically coordinated cluster utilizing a mixed nitrogen- and sulfur-donating ligand is investigated as a model for ligand rearrangement processes during iron sulfur cluster biogenesis. Furthermore, a high fidelity model system for the asymmetrically ligated [2Fe-2S] cluster of mitoNEET proteins is developed and characterized in detail. This cluster and its homoleptic analogue are studied as reagents in proton coupled electron transfer processes, highlighting the role asymmetry and reorganization energy play in tuning this reactivity. The effects of the ligation pattern on entropic contributions during reduction are probed by temperature dependent electrochemical measurements. Finally, synthetic [2Fe-2S] clusters are investigated with respect to their reactivity with organic radicals, mimicking the unique reactivity of biotin synthase. Bücher > Fremdsprachige Bücher > Englische Bücher 210 x 148 x 10 mm , Cuvillier Verlag, Paperback, Cuvillier Verlag<

2017, ISBN: 3736996721

Kartoniert / Broschiert Chemie, bioinorganic; chemistry; iron-sulfur clusters, mit Schutzumschlag 11, [PU:Cuvillier Verlag]

2017, ISBN: 9783736996724

Model Studies Using Synthetic Analogues, Buch, Softcover, [PU: Cuvillier Verlag], Cuvillier Verlag, 2017